Increased eytotoxicity of nanoparticle-carried Adriamycin in vitro and potentiation by verapamil and amiodarone
Identifieur interne : 003127 ( Main/Exploration ); précédent : 003126; suivant : 003128Increased eytotoxicity of nanoparticle-carried Adriamycin in vitro and potentiation by verapamil and amiodarone
Auteurs : Christine Kubiak [France] ; Patrick Couvreur [France] ; Luc Manil [France] ; Bernard Clausse [France]Source :
- Biomaterials [ 0142-9612 ] ; 1989.
English descriptors
- Teeft :
Abstract
Abstract: The cytotoxicities of free cyanoacrylic nanoparticles, free Adriamycin, Adriamycin-loaded nanoparticles and a mixture of Adriamycin and nanoparticles are compared in cancer cell cultures. Increased cytotoxicity was observed in the sensitive (DC3F) subline when Adriamycin was in paniculate form rather than free. In the derived pleiotropic resistant subline (DC3F AD/AZA), sensitivity to Adriamycin was completely restored with the conjugate. Addition of verapamil or amiodarone allowed an enhancement of efficiency of tenfold for free Adriamycin and between two- and fourfold for its conjugate form. Vectorization by nanoparticles and pharmacological modulation of cell membrane can act in synergy to overcome the resistance to Adriamycin in vitro.
Url:
DOI: 10.1016/0142-9612(89)90062-8
Affiliations:
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type="abbrev">JBMT</title><idno type="ISSN">0142-9612</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1989">1989</date><biblScope unit="volume">10</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="553">553</biblScope><biblScope unit="page" to="556">556</biblScope></imprint><idno type="ISSN">0142-9612</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0142-9612</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adriamycin</term><term>Amiodarone</term><term>Cell lines</term><term>Cell membrane modulators</term><term>Cytotoxicity</term><term>Dc3f</term><term>Different drugs</term><term>Ibca</term><term>Ihca</term><term>Nanoparticles</term><term>Potentiation</term><term>Resistant cells</term><term>Subline</term><term>Toxicity</term><term>Tumoural cells</term><term>Verapamil</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The cytotoxicities of free cyanoacrylic nanoparticles, free Adriamycin, Adriamycin-loaded nanoparticles and a mixture of Adriamycin and nanoparticles are compared in cancer cell cultures. Increased cytotoxicity was observed in the sensitive (DC3F) subline when Adriamycin was in paniculate form rather than free. In the derived pleiotropic resistant subline (DC3F AD/AZA), sensitivity to Adriamycin was completely restored with the conjugate. Addition of verapamil or amiodarone allowed an enhancement of efficiency of tenfold for free Adriamycin and between two- and fourfold for its conjugate form. 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